Ebola Outbreak Outpacing Response Efforts at Crisis Epicenter, Officials Warn

In Mongbwalu, a gold-mining town in the Democratic Republic of Congo's Ituri province, four healthcare workers died within a four-day span at the general referral hospital in mid-May [1]. They had been treating patients without knowing Ebola was in their ward. By the time the Bundibugyo strain of Ebola virus was confirmed on May 15, the pathogen had been circulating undetected for weeks — possibly months — across a region already fractured by armed conflict, mass displacement, and the collapse of international health surveillance networks [2].

As of May 25, 2026, the outbreak has reached at least 1,010 cumulative cases across the DRC and Uganda — over 900 suspected and 101 confirmed — with more than 220 deaths [3][4]. WHO Director-General Tedros Adhanom Ghebreyesus was blunt: "We are urgently scaling up operations, but at the moment the epidemic is outpacing us" [3]. The WHO declared the outbreak a Public Health Emergency of International Concern (PHEIC) on May 17, only the eighth such declaration in the organization's history [5].

Source: WHO Disease Outbreak News

Data as of May 25, 2026CSV

A Strain With No Vaccine

The outbreak's central complication is biological. The two licensed Ebola vaccines — Merck's Ervebo and the Johnson & Johnson Mvabea/Zabdeno regimen — target the Zaire ebolavirus. Cross-protection against the Bundibugyo virus, one of six known Ebola species, has not been clinically established [6][7]. There are also no approved therapeutics specifically for this strain.

This means the response cannot rely on ring vaccination, the strategy that proved decisive in containing the 2018–2020 Kivu Ebola outbreak, where over 300,000 people were vaccinated [8]. Instead, containment depends entirely on classical public health measures: case isolation, contact tracing, safe and dignified burials, and community engagement [6].

The Bundibugyo virus carries a historical case fatality rate between 25% and 50% [7]. In the current outbreak, the confirmed case fatality rate stands at roughly 11–12%, with 10 deaths among 85 confirmed cases across both countries as of May 24 [1]. However, the far higher death toll among suspected cases — 176 deaths among 746 suspected cases in the DRC alone — suggests significant underdiagnosis, with many patients dying before samples can be collected or tested [1][9].

The Epicenter: Ituri Under Siege

Three health zones — Mongbwalu, Rwampara, and Bunia — account for 96% of suspected cases and 79% of confirmed cases [1]. These areas sit in the heart of Ituri province, a region that has been convulsed by armed conflict for years. Fighting involving militias and the Islamic State-affiliated Allied Democratic Forces intensified in late 2025, and over the past two months alone, more than 100,000 people have been newly displaced [10][11].

The DRC has 5.2 million internally displaced persons, the fourth-highest total globally [12]. Within Ituri province specifically, nearly one million people are displaced, and 1.9 million are in need of humanitarian assistance [1][10]. Across both Ituri and neighboring provinces, four million people require urgent aid, two million are displaced, and ten million face acute hunger [10].

Source: UNHCR Population Data

Data as of Dec 31, 2025CSV

The displacement creates a particularly hostile environment for outbreak containment. Populations are highly mobile, moving between camps and communities in patterns that make contact tracing extraordinarily difficult. Healthcare workers have been attacked. Roads are impassable in some areas, and armed groups restrict the movement of surveillance teams and block the transport of laboratory samples [9][11].

Contact Tracing: 21% and Falling

The operational metrics reveal the scale of the gap between what is happening and what containment requires. As of May 21, response teams in Ituri province had identified 1,603 contacts — but the follow-up rate stood at just 21% [1]. In Uganda, where 5 confirmed cases had been reported (including cases in the capital Kampala), 127 contacts were being monitored with better follow-up [1][4].

International standards for Ebola containment call for follow-up of at least 90% of identified contacts within 24 hours of identification. The 21% figure in Ituri represents a response operating at less than a quarter of the minimum threshold.

The Centre for Global Infectious Disease Analysis at Imperial College London has estimated the actual case count may already be around 1,000 when accounting for undetected transmission — a figure consistent with the suspected case totals [9][14]. The most affected health zones — Mongbwalu, Rwampara, and Bunia — are semi-urban areas with dense populations and informal healthcare facilities where infection prevention and control measures are weak or absent [1][9].

Médecins Sans Frontières (MSF) has established an isolation ward at Kyeshero Hospital and is training medical staff on Ebola case management [15]. The United States announced funding for up to 50 treatment clinics, to be delivered through the UN's Central Emergency Response Fund [16]. But the response remains far short of what is needed, and the WHO has allocated just $3.9 million from its Contingency Fund for Emergencies [10].

Who Is Getting Sick

Detailed demographic breakdowns remain limited, partly because of the surveillance gaps. What is known suggests patterns consistent with previous Ebola outbreaks: healthcare workers are disproportionately affected (four deaths at Mongbwalu hospital alone), and infection clusters are appearing around funeral and burial practices [1][15].

UNICEF has warned that children are especially vulnerable — not only to direct infection but to cascading disruptions in health services, nutrition, and education that accompany Ebola outbreaks [17]. The high proportion of suspected cases relative to confirmed ones — roughly 9 to 1 — points to communities where people are falling ill and dying without ever reaching a health facility [9].

Community distrust is a significant barrier. Residents in affected areas initially attributed the illness to mystical causes [18]. Social media conspiracy theories have labeled the outbreak a "distraction" or a "hoax" linked to DRC political dynamics, specifically President Félix Tshisekedi's third-term ambitions [10][11]. This mirrors patterns from the 2018–2020 Kivu outbreak, where attacks on Ebola treatment centers and distrust of outside responders prolonged the epidemic for more than 21 months [8][19].

The Funding Collapse

The current outbreak is unfolding against the backdrop of what multiple former officials describe as an unprecedented withdrawal of international health infrastructure from central Africa.

The Trump administration closed USAID in 2025. U.S. foreign spending on global health dropped by nearly 57% [13]. Humanitarian assistance to the DRC specifically fell from over $1.2 billion in fiscal year 2024 to $715 million in fiscal 2025, and then to just $67 million in the first quarter of fiscal 2026 [2][13].

Source: CNN / USAID data

Data as of May 22, 2026CSV

The effects were concrete and immediate. The International Rescue Committee scaled back from covering five health zones in Ituri to two [2]. Community health workers lost their jobs. Stocks of personal protective equipment were depleted. The sample transport logistics that USAID had previously funded — essential for getting specimens from remote clinics to laboratories in Kinshasa — broke down, with flight cancellations and improperly handled shipments degrading samples [2][11].

"When you dismantle those programs, you no longer have your frontline eyes and ears on the ground that can alert you," said Ana Bodipo-Mbuyamba, a former USAID health director in DRC [2].

Grace Tran, who worked on USAID Ebola preparedness, put it directly: "Outbreaks are always going to occur. It's more the fact that it circulated for so long, and this thing is much bigger than we've realized" [2].

The cuts were not exclusively American. The United Kingdom, Germany, and Canada also reduced foreign aid for global health and development in 2025 [13]. The Trump administration's withdrawal from WHO — which had already prompted staff reductions at the organization — left a gap that no other donor country filled. WHO's unpaid assessed contributions totaled nearly $360 million at the end of 2025 [13].

Salim Abdool Karim, a member of the Africa CDC's emergency committee, offered a stark assessment: "The reality is that the U.S. government is missing in action" [2].

The Case Against International Agencies

The debate over responsibility is not one-sided. While local governance failures — corruption, political instability, the DRC government's slow initial response — are real, a strong case exists that international institutions bear significant blame for the gap between transmission and response.

First, the failure to develop vaccines or therapeutics for non-Zaire Ebola species despite decades of awareness represents a systemic failure of global health research priorities. The Bundibugyo virus was first identified in 2007 in Uganda. Nineteen years later, there is no vaccine [7].

Second, the pre-positioning of response stockpiles and health system capacity between outbreaks was inadequate. The DRC has experienced more than a dozen Ebola outbreaks since 1976. Yet the health infrastructure in Ituri — a known conflict zone with recurring displacement — remained fragile, dependent on foreign-funded community health workers and externally supplied equipment [2][11].

Third, the response activation timeline has drawn criticism. The virus circulated for weeks before detection, and the PHEIC was not declared until May 17, by which point case counts were already in the hundreds [5][9]. During the 2014–2016 West Africa outbreak, which killed over 11,000 people, a similar pattern of delayed international mobilization allowed the epidemic to grow beyond containment before resources arrived [10][20].

The WHO itself has acknowledged these structural vulnerabilities. At the World Health Assembly opening on May 19, discussions took place "under the shadow of Ebola, hantavirus, and funding cuts" [13].

Lessons From Outbreaks That Were Eventually Contained

The 2018–2020 Kivu Ebola outbreak is the most relevant precedent. That outbreak, also in eastern DRC, faced nearly identical challenges: armed conflict, displacement, community distrust, and attacks on health workers. It grew to 3,470 cases over 21 months — the second-largest Ebola outbreak in history at the time — before being contained [8][19].

Several interventions proved decisive. Intensive community engagement, including hiring local residents to lead response activities rather than relying on outside teams, gradually rebuilt trust [19][20]. Decentralized care — bringing treatment and testing closer to affected communities rather than requiring patients to travel to centralized facilities — reduced barriers to care-seeking. Ring vaccination with Ervebo, which eventually reached over 300,000 people, created firebreaks around transmission chains [8].

Timing also mattered. Interventions deployed during periods of relative security were far more effective than those attempted amid active fighting [19][20]. And the cumulative effect of 55 million health screenings and surveillance of contacts — resource-intensive but effective — eventually outpaced transmission [8].

The critical question is whether these conditions can be replicated in the current outbreak. The absence of a vaccine removes one of the most powerful tools. The security environment in Ituri is, by most accounts, worse than during the Kivu outbreak. And the international funding and personnel infrastructure is substantially degraded compared to 2018 [2][11][13].

What Comes Next

The outbreak is now the third-largest in recorded Ebola history and continues to grow [13]. Cases have appeared in three DRC provinces, in Uganda's capital Kampala, and one American national has been confirmed positive and transferred to Germany for treatment [1][4]. Italy has reported two suspected cases linked to Uganda travel [3].

The U.S. announcement of 50 treatment clinics represents a significant, if belated, commitment [16]. But the clinics must still be built, staffed, and supplied in a conflict zone with degraded logistics. The gap between pledged and operational capacity remains wide.

Imperial College London researchers have emphasized that non-pharmaceutical interventions — the only tools available against Bundibugyo — become "very resource-intensive as soon as case numbers are large" and are "challenging to implement especially in large urban centers, highly connected areas, or areas impacted by conflict" [14]. The current outbreak presents all three conditions simultaneously.

The trajectory of the next several weeks will depend on whether the international community can mobilize resources at a speed that exceeds transmission — a race that, by every available metric, it is currently losing.