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An international team of 16 scientists has published a landmark research agenda in PNAS outlining a systematic strategy to achieve room-temperature superconductivity, combining AI-driven materials screening with advanced engineering techniques. The roadmap arrives amid genuine breakthroughs in nickelate and hydride superconductors — and in the aftermath of high-profile fraud scandals that shook the field — marking a pivotal moment in the century-long quest for zero-resistance electrical conduction at everyday temperatures.