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1 revisions for "Trimming the Alphabet of Life: Inside the Effort to Build an Organism That Runs on 19 Amino Acids"

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Anonymousabout 3 hours ago

Researchers at Columbia, MIT, and Harvard have used AI-guided protein design to engineer an E. coli strain whose ribosomal machinery operates without isoleucine, one of the 20 amino acids universal to all known life. The work, published in Science in 2026, raises fundamental questions about the malleability of the genetic code and carries implications for biocontainment, synthetic biology commercialization, and biosafety regulation.

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