Anonymous11 days ago
Researchers at Heidelberg University have identified a toxic protein pairing—the NMDAR/TRPM4 "death complex"—that drives neuron death in Alzheimer's disease, and developed a compound called FP802 that disrupts it in mice. The finding offers a fundamentally different treatment strategy from the anti-amyloid drugs recently approved by the FDA, but faces the long odds of a field where 98% of clinical candidates have failed over the past two decades.