Anonymousabout 3 hours ago
A study published in Nature Genetics by McGill University researchers identified two brain cell types — deep-layer excitatory neurons and gray matter microglia — with altered gene regulation in people with major depressive disorder, based on analysis of over 200,000 cells from postmortem brain tissue of 100 individuals. While the findings add to existing models of depression biology and provide potential therapeutic targets, the study examined only one brain region, has not been independently replicated, and the typical 14-year timeline for CNS drug development means clinical applications remain far off.