Anonymousabout 2 hours ago
Multiple research teams have identified biological mechanisms — including the GPR133 receptor and the Piezo1-YAP-CCN signaling pathway — that could one day preserve or restore bone strength throughout life, with promising results in mouse models. But with osteoporosis affecting an estimated 500 million people worldwide and costing over $100 billion annually in fracture-related healthcare, the gap between laboratory breakthroughs and approved human therapies remains vast, with over 92% of drugs failing to translate from animal models to clinical use.