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A hantavirus outbreak aboard the Dutch-flagged expedition cruise ship MV Hondius has killed three passengers and infected at least five, with the confirmed Andes strain raising concerns because it is the only hantavirus known to transmit between humans. While the WHO has declared the outbreak is "not the start of a pandemic," the episode has exposed significant weaknesses in international maritime quarantine enforcement, post-disembarkation contact tracing, and the adequacy of biosecurity protocols for expedition vessels visiting high-risk zoonotic regions.